Find answers in our support articles. Page 1 of 8. ETHOCEL premium ethylcellulose resins are water-insoluble polymers. Go to Investor Relations. In Cellulose and Cellulose Derivatives in the Food Industry, T. Wstenberg (Ed. Microcrystalline cellulose is a commonly used excipient in the . It does not interfere with other nutrients when added to food products, and is instead, an excellent carrier and stabiliser, helping prolong the viability of food products. Aquacoat sustained release coating is a pseudo latex aqueous dispersion of water insoluble polymers used for sustained and enteric coating applications. JRS Pharma: PROSOLV SMCC 90: Microcrystalline Cellulose, Colloidal Silicon Dioxide: 125: 0.25 - 0.37: Formulas in which a balance of flow and compaction is required. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. Avicel Microcrystalline cellulose is manufactured in the United States of America by Dupont. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. %
As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. };khd5x=fr 1 0 obj
FMC Corporation. Catalog Number 102331. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Thus, Avicel contributes no or very few calories to the food system. %PDF-1.5
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In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Standard, 29 CFR 1910.1200 and Canada's Workplace Hazardous Materials Information System (WHMIS . However, consumption of large quantities of the material may have a laxative effect. /Producer(Sub Systems, Inc.)/CreationDate(D:20211228124915+05'00')/ModDate(D:20211228124915+05'00')/Creator(Sub Systems, Inc.)
Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. (Microcrystalline Cellulose) DATE PREPARED: 1/7/2016 Page 1 of 4 Section 1. Co-processed excipients deliver functional synergies to address formulation challenges with simplified, single ingredient solutions. PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME: Avicel PC 611 Microcrystalline Cellulose CHEMICAL FAMILY: Carbohydrate, Cellulose Derivative SYNONYMS: Microcrystalline cellulose (INCI name): MCC, cellulose gel; Sodium Carboxymethylcellulose: NaCMC, CMC, SCMC, Carboxymethylcellulose GENERAL USE: Personal Care MANUFACTURER
FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 (General Information) msdsinfo@fmc.com (Email - General Information)
FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Ireland) 2. Cellulose microcrystalline. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. However, it yields non-digestible fibre. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. . %
The data shown below apply only to Avicel PH 101. Assay for carboxymethycellulose sodium, wt % 8.3 to 13.8 . Eur., JPE . zW0}
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?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication MATERIAL SAFETY DATA SHEET Version: 1.0 1. Quantity: 1 700 kgs. Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. : 1. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . <>
1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. An internally cross-linked sodium carboxymethyl cellulose (NaCMC), it aids in the disintegration and drug dissolution of pharmaceutical tablets, capsules, and granules. <>
F. Lerk, G.K. Bolhuis, A.H. De Boer, Effect of Microcrystalline Cellulose on liquid penetration in and disintegration of directly compressed tablets, Journal of Pharmaceutical Sciences, 68 (1979) 205-211. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. /MediaBox [0 0 612 792]
Hi, let us know if you have any questions as you visit our website. In summary, Avicel microcrystalline cellulose is virtually inert, its energy content is very low or zero and it is not absorbed. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. The most. ChemicalBook. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (
FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. Are you looking for information about products and services by region? %PDF-1.4
Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . (Microcrystalline Cellulose Market Pr. . Microcrystalline Cellulose Side Effects. 1.3. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. CAS #: 9004-34-6 . 0.25 - 0.37. Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& No. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. 2 0 obj
} !1AQa"q2#BR$3br At the same time, its pronounced shear-thinning behavior enables handling of even highly viscous solutions. 4. X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? q9;v80q>jZ We respect your privacy FMC Privacy Policy. LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such as non-stick coatings, insulation of wiring, crop protection and paints,coats and inks. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. endobj
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kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM FMC BioPolymer 1735 Market Street Philadelphia, PA 19103 (800) 526-3649 . Combines good flow and high compactibility. 6 Frijlink, Compaction mechanism and tablet strength of unlubricated and lubricated (silicified) Microcrystalline Cellulose, European journal of Pharmaceutics and Biopharmaceutics, 59 (2005) 133-138. Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Page 1 of 9. Biologicals by FMC. [FMC Study Number I92-1464]. 130. /Type/Page
Report Category. Buy Chemicals. FMC has deep roots in the food production system worldwide learn more about our latest advances in the future of agriculture. B;vLZpHU%ChUyD+[ Test Data Available. The figure below illustrates the structural organisation of cellulose within plants. 6 0 obj
CAS 9004-34-6. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >>
The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. iQuLyI4D@yq#u0dZt=0?QUz{K6by_C"vW~Nj$bo? 4 0 obj
Alginates from IFF are an excellent choice for consistent performance in a variety of applications. G2W4de=u183KGH{ vQ#4:1\wc GRINDSTED Xanthan Gum readily dissolves in water under ambient conditions without the need of special high-shear equipment. Chemical Name Microcrystalline cellulose (INCI Name): MCC, cellulose gel Common Name Avicel PH105 Microcrystalline Cellulose CAS Number 9004-34-6 Impurities and/or Stabilizing Additives No data available Section 4: First Aid Measures General Advice No data available If Inhaled Remove person to fresh air. By utilizing proprietary co-processing technologies, Dupont also manufactures LATTICE NTC products. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. }o]X4]. Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. The table below shows the most common physicochemical parameters of this raw material. If breathing is difficult or if . Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q
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U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Explore how you can develop your career and bring your creative ideas to life at IFF. Magazine: Material safety data sheet - FMC Corporation. CAS 9004-34-6, pH 5 - 7.5. In 1964 FMC, Corporation . : 9004-34-6 Date Approved: 01/31/2008 . Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. It flows and compresses extremely well, properties that endear this material wide scope of use in many fields. gwf;J(e0o|1p{R~P^);ao!%{0KD7. stream EINECS #: 232-674-9 1.7. >>
Revision No. 1.3. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm SDS. Avicel Microcrystalline Cellulose: Chemical Identifiers. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . In large quantities it provides dietary bulk and may lead to a laxative effect. Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. Learn about FMC's industry leading goal of net-zero emissions by 2035. The process is relatively basic; and starts with treating cellulose, obtained as a high-grade pulp obtained from fibrous plant material, with mineral acids, followed by purification and spray-drying. gac74
[#B6`Wnw7 There have always been two different points of view for the liquidity of MCC. You have already flagged this document.Thank you, for helping us keep this platform clean.The editors will have a look at it as soon as possible. Microcrystalline Cellulose (MCC) Manufacturing Industry. Low use levels of GRINDSTED Xanthan Gum are sufficient to provide desired viscosities and textures. It is a white, free-flowing powder. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . pfTr^i5wOg)y .6
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Fiber supplements can lessen the absorption of some . SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). J]3yzZ2Z$mZ7o%-Xyq'()V9KX0gk~AA
Cu:3(]N"AQdUt~h|P Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. However, if handling bulk powders, observance of appropriate safeguards is recommended. . Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. {iy7uEijn0y]"s"gbV~p8Q)zN:cyvs]&,kk=6pcA %iBW|2nKa)Jb7` 0
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II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45.
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